The cheapest way to get from Prague Airport (PRG) to Hotel Thermal, Karlovy Vary costs only 173 Kč, and the quickest way takes just 1¾ hours. Find the travel option that best suits you. Since the 18th century, Russians have flocked to the healing waters of Karlovy Vary. Now, the Czech government has barred them from visiting the country, and the town must reinvent itself. From Prague’s main station Praha Hlavni Nadrazi and Praha Holesovice railway station, you can catch a train and get to Karlovy Vary in around 3 hours. Trains depart only a few times a day so be sure to book tickets in advance. By car. Karlovy Vary is connected to Prague with the D6 highway that goes all the way to Cheb, near the border of The King of Bohemia, and Holy Roman Emperor, Charles IV founded Karlovy Vary. His capital city was Prague, only 120 kilometers away. So, he would take his men hunting near the confluence of the two rivers, the Ohře and Teplá, where he and his men discovered the steaming waters. Fly from Munich (MUC) to Leipzig (LEJ) Take the train from Leipzig/Halle Flughafen to Zwickau, Hauptbahnhof. Take the train from Zwickau (Sachs)Hbf to Karlovy Vary. 8h 14m. Quickest way to get there Cheapest option Distance between. You can take a train from Regensburg to Karlovy Vary via Marktredwitz and Cheb in around 4h 11m. Alternatively, you can take a bus from Regensburg to Karlovy Vary via Marktredwitz station in around 4h 18m. Train operators. Die Länderbahn. Deutsche Bahn Regional. Full description. Karlovy Vary is the best known spa town in the Czech Republic, and its history dates to the 14th century and the reign of Charles IV. The healing powers of the local springs enticed notables such as the Russian Tsar Peter the Great and the German poet Goethe. The spa town is also known for the production of world-renowned The cheapest way to get from Karlovy Vary to Krakow costs only $777, and the quickest way takes just 18½ hours. Find the travel option that best suits you. The best way to get from Karlovy Vary to Prague Florenc is to bus which takes 2h and costs 160 Kč - 430 Kč. Alternatively, you can train, which costs 380 Kč - 850 Kč and takes 3h 32m. FlixBus operates a bus from Karlovy Vary to Prague every 2 hours. Tickets cost 300 Kč - 430 Kč and the journey takes 2h. Getting to Karlovy Vary from Prague. Can you do Prague to Karlovy Vary as a day trip? Yes. But don’t take the train. The bus is much quicker. It takes a bit more than 2 hours from Florenc Bus Station in Prague. To get to Karlovy Vary from Prague by car, take highway E48. Another option to get from Prague to Karlovy Vary is by taxi or private car. ocUsNSZ.